Evaluation of the anti-angiogenic action of melatonin in breast cancer
نویسندگان
چکیده
Background Once a tumor lesion exceeds a few millimeters in diameter, hypoxia triggers a cascade of events to allow angiogenesis and tumor progression. As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. Melatonin has been suggested to inhibit angiogenesis in cancers, although this effect has not been described in breast cancer. We evaluated the effects of melatonin treatment on angiogenesis in breast cancer.
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